PEA (wisepowder Palmitoylethanolamide) is a chemical made from fat. It belongs to a group of Amide known as fatty acid Amide which is endogenous in nature. It is a saturated N-acylethanolamidein endocannabinoid family. Endocannabinoids are molecules that bind to Cannabinoid receptors involved in neuromodulatory activities in the body. This fatty acid Amide belongs to a class of nuclear factor agonists. It is found naturally in some fruits like egg, milk and in human body. It functions in binding different nuclear receptor molecules. It’s use is wide in medical fields like treating pain, fibromyalgia etc. It is hence known as a natural painkiller.

PEA has been widely studied for various therapeutic areas in thousand of adults but not in children. PEA is not a supplement to start with but for those who have a knowledgeable healthcare team, they can take PEA with their consultation. Make sure that a specific diet plan is followed to know if PEA is really needed for body or not.PEA has been first described by scientist in 1957.

Composition and nature of Palmitoylethanolamide

PEA(Palmitoylethanolamide) belongs to a group of amides i.e. fatty acid amides. It’s IUPAC name is N-(2-Hydroxyethyl) hexadecanamide having a chemical formula of C18H37NO2. Wisepowder Palmitoylethanolamide is eighteen molecules of carbon, thirty-seven molecules of hydrogen, one molecule of nitrogen and two molecules of oxygen. Other chemical names ofPalmitoylethanolamide is Hydroxyethylpalmitamide, Palmidrol, N-palmitoylethanolamine and Palmitylethanalamide.PEA has an appearance like a white crystal which has density of 910mg/mL and molar mass of 299.499gm/mol.It’s melting point is 93 to 98 degree centigrade or 366 to 371 Kelvin.PEA is a Peroxisome Proliferator activated receptor alpha complex(PPAR-Alpha). It has an affinity for cannabinoids but aversion towards CB1 and CB2 and so it can’t be said to be aendocannabinoid.

Uses and benefits of Palmitoylethanolamide

There are many use of PEA has been found in medicine sector like

  • It is a natural painkiller- PEA blocks mast cells which blocksinflammation pathway and causes pain. It has neuroprotective, anti-inflammatory, anti-nociceptive and anti-convulsant property. PEA is a fatty molecule that supports to mylein nerve sheath for better nerve function.
  • It helps to treat fibromyalgia- In women, the chronic pain in trapezius muscle is caused due to deficiency of Palmitoylethanolamide and the body required PEA supplements.
  • It helps to cure chronic regional pain syndrome- PEA has been proved to cure CRPA. If a person has been suffering from CRPS, they a regular dose of PEA can cure the problem.
  • It is used inneurotherapy- PEA has anti-inflammatory and analgesic properties which helps in treating neuropathic pains in humans. For these properties of PEA is has also been used to cure nerve compression syndrome. It has protective and repairative functions.

Studies found out no serious side effects of consuming PEA. It has some mild symptoms like upset stomach if taken continuously for 3 months. Pregnant and breastfeeding women should consult their doctors before consuming it.


PEA has many benefits like wisepowder Pyrroloquinoline quinone (PQQ) in curing pains like neuropathic pain and regional pain syndrome. Still it is advised to take any medication with the consultation of the doctor. It is widely used as a pain killer due to its anti-inflammatory, analgesic properties.

By Sienna